A new study has established a definitive link between neuropsychiatric disorders and dental health. This research represents a major milestone in modern medical diagnostics, unveiling the potential of salivary biomarker profiling as a non-invasive and highly predictive tool for disease detection.
With this study, researchers have successfully demonstrated that changes in salivary Vitamin D and Brain-Derived Neurotrophic Factor (BDNF) levels can serve as a dual diagnostic marker, effectively detecting both periodontal disease and neuropsychiatric conditions. The findings herald a potential shift in how healthcare professionals can approach disease prevention, diagnosis, and management—bridging the gap between oral health and mental well-being.
What the study found
Traditionally, periodontal disease has been diagnosed through clinical examinations and radiographic imaging, whereas neuropsychiatric disorders have relied on subjective assessments of symptoms. However, this study redefines disease detection by providing an objective, biochemical-based, and non-invasive diagnostic approach through saliva analysis.
Researchers from the Department of Periodontics, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, conducted the study, which involved a comprehensive evaluation of neuropsychiatric patients from various tertiary medical centres, ensuring a diverse and clinically relevant patient population. A structured psychiatric assessment was conducted using the General Health Questionnaire (GHQ-28) to categorise patients based on their psychological well-being. This tool effectively screened for somatic symptoms, anxiety, social dysfunction, and depression, allowing researchers to correlate mental health status with dental diseases through biological markers.
Two biological markers, namely Vitamin D and BDNF, were quantified from saliva. Researches in the past have reported that vitamin D helps keep bones strong, supports the immune system, and protects brain health, while BDNF is important for nerve cell growth, brain function, and memory. The study revealed that these two markers are connected, and play a role in both mental health and oral health.
The following key findings emerged:
Correlation between psychological distress and salivary biomarkers: Patients with high GHQ-28 scores, indicating severe mental distress, had low levels of BDNF and Vitamin D in their saliva, reinforcing the hypothesis that systemic inflammation and neuronal health are intrinsically linked.
Increased oral inflammation was seen with further depletion of salivary BDNF and Vitamin D, suggesting that dental diseases may aggravate mental illness.
The study further confirmed that salivary BDNF and Vitamin D markers can serve as effective, non-invasive indicators for both periodontal and neuropsychiatric disease risk, allowing for early-stage intervention and prevention of both oral and neurological diseases.
These findings reinforce the concept that oral and mental health are intricately connected, demanding an integrated, interdisciplinary approach to disease prevention and treatment.
Towards a unified healthcare model
This study paves the way for the future of healthcare, where dental, psychiatric, and systemic health professionals can collaborate to provide comprehensive, patient-centred treatment strategies. Some of these can include:
Integration of salivary biomarkers into routine screening: Encouraging dental and psychiatric professionals to adopt salivary biomarker screening for dual disease detection.
Personalised healthcare approaches: Merging biomarker-driven diagnostics with lifestyle-based interventions to improve treatment outcomes.
Public health implications: Leveraging this study’s findings to develop nationwide screening programs, particularly for high-risk populations such as individuals with chronic stress, metabolic disorders, and immunocompromised conditions.
A holistic approach
In addition to biomarker-based diagnostics, the study advocates a holistic approach to health, emphasising the role of lifestyle interventions in the prevention of dental and neurological diseases. Researchers have also worked on the effect of yoga practices and meditation on oral diseases and further highlighted the importance of yoga practices as powerful adjuncts in managing both mental and oral health.
Yoga has been shown to reduce oxidative stress, enhance immune function, and regulate inflammatory pathways, which are crucial for both periodontal and mental health. It promotes better circulation, oxygenation, and tissue healing, which may aid in periodontal regeneration.
Scientific evidence also suggests that meditation increases BDNF levels, improving cognitive function and emotional resilience. It plays a key role in stress modulation and reducing cortisol levels, which are implicated in periodontal tissue destruction and mental distress.
Chronic stress and anxiety have been identified as major risk factors for both periodontal disease and neuropsychiatric disorders. Practicing yoga and meditation helps in balancing the autonomic nervous system, reducing pro-inflammatory responses, and improving oral hygiene behaviours.
Based on these findings, future healthcare approaches should include early dental check-ups and preventive care, and must incorporate yoga and mindfulness practices, to improve both oral health and mental well-being.
The path ahead
This research represents a significant advancement in healthcare, changing the way oral and mental health are understood, diagnosed, and treated. By using saliva-based markers, personalised treatment approaches, and holistic wellness strategies, this study offers a new and innovative path toward better healthcare.
As global research continues to unravel the systemic connections between oral and mental health, this pioneering study sets a new standard for future interdisciplinary investigations. The implementation of biomarker-driven diagnostics, coupled with evidence-based wellness practices, holds immense potential in creating a healthier, more resilient population.
(Dr. Jaideep Mahendra is professor and head, department of periodontics, Meenakshi Ammal Dental College and Hospital, Chennai. Email: [email protected])
Published – June 07, 2025 11:00 am IST