Armed with some data from our friends at CrunchBase, I broke down the largest US startup funding rounds from March 2025. I have included some additional information such as industry, company description, round type, founders, and total equity funding raised to further the analysis.
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11. Lila Sciences $200.0M
Round: Seed
Description: Cambridge-based Lila Sciences creates a scientific superintelligence platform and autonomous labs for life sciences, chemistry, and materials science. Founded by Molly Gibson and Noubar Afeyan in 2023, Lila Sciences has now raised a total of $200.0M in total equity funding and is backed by General Catalyst, Modi Ventures, Flagship Pioneering, March Capital, and Abu Dhabi Investment Authority.
Investors in the round: Abu Dhabi Investment Authority, Altitude Life Science Ventures, ARK Venture Fund, Blue Horizon Advisors, Flagship Pioneering, General Catalyst, March Capital, Modi Ventures, State of Michigan Retirement System
Industry: Artificial Intelligence (AI), Life Science, Software
Founders: Molly Gibson, Noubar Afeyan
Founding year: 2023
Location: Cambridge
Total equity funding raised: $200.0M
10. Shield AI $240.0M
Round: Series F
Description: San Diego-based Shield AI is a deep-tech company that focuses on developing AI-powered systems to enhance the safety of service members and civilians. Founded by Andrew Reiter, Brandon Tseng, and Ryan Tseng in 2015, Shield AI has now raised a total of $1.0B in total equity funding and is backed by Andreessen Horowitz, Founder Collective, Riot Ventures, US Innovative Technology Fund, and Bloomberg Beta.
Investors in the round: Andreessen Horowitz, Cacti, Hanwha Aerospace, L3Harris Technologies, US Innovative Technology Fund, Washington Harbour Partners
Industry: Artificial Intelligence (AI), Autonomous Vehicles, Drones, Machine Learning, National Security
Founders: Andrew Reiter, Brandon Tseng, Ryan Tseng
Founding year: 2015
Location: San Diego
Total equity funding raised: $1.0B
9. Celestial AI $250.0M
Round: Series C
Description: Santa Clara-based Celestial AI develops an optical interconnect technology platform for data center and AI computing solutions. Founded by David Lazovsky, Michelle Tomasko, and Preet Virk in 2020, Celestial AI has now raised a total of $588.9M in total equity funding and is backed by BlackRock, Temasek Holdings, Tiger Global Management, US Innovative Technology Fund, and Fidelity.
Investors in the round: AMD Ventures, BlackRock, Engine Ventures, Fidelity, Koch Disruptive Technologies, Lip-Bu Tan, Maverick Silicon, Porsche Automobil Holding, Temasek Holdings, Tiger Global Management, Xora Innovation
Industry: Artificial Intelligence (AI), Data Center, Machine Learning, Semiconductor, Software
Founders: David Lazovsky, Michelle Tomasko, Preet Virk
Founding year: 2020
Location: Santa Clara
Total equity funding raised: $588.9M
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9. Epirus $250.0M
Round: Series D
Description: Torrance-based Epirus builds directed energy and power management systems to solve some of the world’s most complex problems. Founded by Bo Marr, Grant Verstandig, Joe Lonsdale, John Tenet, Max Mednik, and Nathan Mintz in 2018, Epirus has now raised a total of $537.4M in total equity funding and is backed by National Science Foundation, StepStone Group, 8VC, Gaingels, and I Squared Capital.
Investors in the round: 8VC, Anchor Capital GP, Centaurus Capital, Center15 Capital, Gaingels, General Dynamics Land Systems, Manhattan Venture Partners (MVP), NightDragon, Oppenheimer & Co., Protagonist, StepStone Group, T. Rowe Price, Washington Harbour Partners
Industry: Aerospace, Machinery Manufacturing, Military, Software
Founders: Bo Marr, Grant Verstandig, Joe Lonsdale, John Tenet, Max Mednik, Nathan Mintz
Founding year: 2018
Location: Torrance
Total equity funding raised: $537.4M
8. Island $250.0M
Round: Series E
Description: Dallas-based Island offers an enterprise browser that enhances security and productivity by integrating essential tools. Founded by Dan Amiga and Michael Fey in 2020, Island has now raised a total of $810.0M in total equity funding and is backed by Sequoia Capital, Insight Partners, Cisco Investments, Coatue, and Canapi Ventures.
Investors in the round: Canapi Ventures, Coatue, Cyberstarts, Georgian, Insight Partners, Sequoia Capital
Industry: Cyber Security, Enterprise Software, Information Technology, Web Browsers
Founders: Dan Amiga, Michael Fey
Founding year: 2020
Location: Dallas
Total equity funding raised: $810.0M
7. Flock Safety $275.0M
Round: Series F
Description: Atlanta-based Flock Safety provides end-to-end surveillance solutions to support law enforcement and communities. Founded by Garrett Langley and Matt Feury in 2017, Flock Safety has now raised a total of $655.6M in total equity funding and is backed by Y Combinator, Andreessen Horowitz, Founders Fund, Spark Capital, and Kleiner Perkins.
Investors in the round: Andreessen Horowitz, Bedrock, Founders Fund, Greenoaks, Kleiner Perkins, Matrix, Meritech Capital Partners, Sands Capital Ventures, Tiger Global Management, Y Combinator
Industry: Manufacturing, Public Safety, Security, Sensor
Founders: Garrett Langley, Matt Feury
Founding year: 2017
Location: Atlanta
Total equity funding raised: $655.6M
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6. Mercury $300.0M
Round: Series C
Description: San Francisco-based Mercury provides online banking solutions for startups and technology-focused businesses. Founded by Immad Akhund, Jason Zhang, and Max Tagher in 2017, Mercury has now raised a total of $452.2M in total equity funding and is backed by Andreessen Horowitz, Sequoia Capital, Spark Capital, 500 Global, and Coatue.
Investors in the round: Andreessen Horowitz, Coatue, CRV, Marathon Management Partners, Sequoia Capital, Spark Capital
Industry: Banking, Financial Services, FinTech, Information Technology, InsurTech
Founders: Immad Akhund, Jason Zhang, Max Tagher
Founding year: 2017
Location: San Francisco
Total equity funding raised: $452.2M
5. Fleetio $450.0M
Round: Series D
Description: Birmingham-based Fleetio is a fleet maintenance management software that helps businesses manage their fleet operations and optimize maintenance workflows. Founded by Tony Summerville in 2011, Fleetio has now raised a total of $620.1M in total equity funding and is backed by Endeavor Catalyst, Bossa Invest, Elephant, and Goldman Sachs Alternatives.
Investors in the round: Elephant, Goldman Sachs Alternatives
Industry: Automotive, Fleet Management, SaaS, Software
Founders: Tony Summerville
Founding year: 2011
Location: Birmingham
Total equity funding raised: $620.1M
4. Nerdio $500.0M
Round: Series C
Description: Chicago-based Nerdio offers cloud solutions to streamline IT management, focusing on Microsoft Azure and virtual desktop optimization. Founded by Joseph Landes and Vadim Vladimirskiy in 2016, Nerdio has now raised a total of $625.0M in total equity funding and is backed by General Atlantic, StepStone Group, Lead Edge Capital, Updata Partners, and MK Capital.
Investors in the round: General Atlantic, Lead Edge Capital, StepStone Group
Industry: Cloud Computing, Information Services, Information Technology, Software
Founders: Joseph Landes, Vadim Vladimirskiy
Founding year: 2016
Location: Chicago
Total equity funding raised: $625.0M
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3. X (formerly Twitter) $1.0B
Round: Venture
Description: Bastrop-based X is a social networking platform that allows its users to send and read microblogs. Founded by Biz Stone and Jack Dorsey in 2006, X (formerly Twitter) has now raised a total of $12.1B in total equity funding and is backed by Andreessen Horowitz, Sequoia Capital, Insight Partners, Union Square Ventures, and Slow Ventures.
Investors in the round: 1789 Capital, Bossa Invest, Darsana Capital Partners, Elon Musk, Manhattan Venture Partners (MVP)
Industry: Blogging Platforms, Social Media, Social Network, Web3
Founders: Biz Stone, Jack Dorsey
Founding year: 2006
Location: Bastrop
Total equity funding raised: $12.1B
2. Anthropic $3.5B
Round: Series E
Description: San Francisco-based Anthropic is an AI research company that focuses on the safety and alignment of AI systems with human values. Founded by Daniela Amodei, Dario Amodei, Jack Clark, Sam McCandlish, and Tom Brown in 2021, Anthropic has now raised a total of $12.9B in total equity funding and is backed by General Catalyst, Menlo Ventures, Lightspeed Venture Partners, Bessemer Venture Partners, and Google.
Investors in the round: Bessemer Venture Partners, Cisco Investments, D1 Capital Partners, Fidelity, General Catalyst, Jane Street Capital, Lightspeed Venture Partners, Menlo Ventures, Salesforce Ventures
Industry: Artificial Intelligence (AI), Generative AI, Information Technology, Machine Learning
Founders: Daniela Amodei, Dario Amodei, Jack Clark, Sam McCandlish, Tom Brown
Founding year: 2021
Location: San Francisco
Total equity funding raised: $12.9B
1. OpenAI $40.0B
Round: Venture
Description: San Francisco-based OpenAI creates artificial intelligence technologies to assist with tasks and provide support for human activities. Founded by Andrej Karpathy, Durk Kingma, Elon Musk, Greg Brockman, Ilya Sutskever, John Schulman, Pamela Vagata, Sam Altman, Trevor Blackwell, Vicki Cheung, and Wojciech Zaremba in 2015, OpenAI has now raised a total of $57.6B in total equity funding and is backed by Andreessen Horowitz, Y Combinator, NVIDIA, Sequoia Capital, and HSBC.
Investors in the round: Altimeter Capital, Coatue, Microsoft, SoftBank, Thrive Capital
Industry: Artificial Intelligence (AI), Generative AI, Machine Learning, Natural Language Processing, SaaS
Founders: Andrej Karpathy, Durk Kingma, Elon Musk, Greg Brockman, Ilya Sutskever, John Schulman, Pamela Vagata, Sam Altman, Trevor Blackwell, Vicki Cheung, Wojciech Zaremba
Founding year: 2015
Location: San Francisco
Total equity funding raised: $57.6B
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